SCOPe 2.07: Domain d4i0fa1: 4i0f A:58-453

Lineage for d4i0fa1 (4i0f A:58-453)

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (329 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d4i0fa1: 4i0f A:58-453 [222822]
   Other proteins in same PDB: d4i0fa2
   automated match to d4i0za_
   complexed with 1bf, zn

Details for d4i0fa1

PDB Entry: 4i0f, 1.8 Å

PDB Description: Design and Synthesis of Thiophene Dihydroisoquinolins as Novel BACE-1 Inhibitors

PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d4i0fa1:

Sequence, based on SEQRES records:

>d4i0fa1 b.50.1.2 (A:58-453) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
gsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrql
sstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwe
gilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmii
ggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrl
pkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsf
ritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfav
sachvhdefrtaavegpfvtldmedcgynipqtdes

Sequence, based on observed residues (ATOM records):

>d4i0fa1 b.50.1.2 (A:58-453) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
gsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrql
sstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwe
gilglayaeiarpddslepffdslvkqthvpnlfslqlcglasvggsmiiggidhslytg
slwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavk
sikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqyl
rpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefr
taavegpfvtldmedcgynipqtdes

Timeline for d4i0fa1:

• d4i0fa1 first appeared in SCOPe 2.03, called d4i0fa_
  
• d4i0fa1 appears in SCOPe 2.06
  
• d4i0fa1 appears in the current release, SCOPe 2.08