Lineage for d4i0ea1 (4i0e A:58-453)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2058814Fold b.50: Acid proteases [50629] (1 superfamily)
    barrel, closed; n=6, S=10, complex topology
  4. 2058815Superfamily b.50.1: Acid proteases [50630] (4 families) (S)
  5. 2060177Family b.50.1.2: Pepsin-like [50646] (11 protein domains)
    duplication: consists of two similar barrel domains
    N-terminal: barrel, partly opened; n*=6, S*=10
  6. 2060235Protein beta-secretase (memapsin) [50671] (1 species)
  7. 2060236Species Human (Homo sapiens) [TaxId:9606] [50672] (281 PDB entries)
    Uniprot P56817 58-446 ! Uniprot P56817 60-447
  8. 2060354Domain d4i0ea1: 4i0e A:58-453 [222821]
    Other proteins in same PDB: d4i0ea2
    automated match to d4i0za_
    complexed with 1b8, zn

Details for d4i0ea1

PDB Entry: 4i0e (more details), 1.7 Å

PDB Description: Design and Synthesis of Thiophene Dihydroisoquinolins as Novel BACE-1 Inhibitors
PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d4i0ea1:

Sequence, based on SEQRES records: (download)

>d4i0ea1 b.50.1.2 (A:58-453) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
gsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrql
sstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwe
gilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmii
ggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrl
pkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsf
ritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfav
sachvhdefrtaavegpfvtldmedcgynipqtdes

Sequence, based on observed residues (ATOM records): (download)

>d4i0ea1 b.50.1.2 (A:58-453) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
gsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrql
sstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwe
gilglayaeiarpddslepffdslvkqthvpnlfslqlcglasvggsmiiggidhslytg
slwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavk
sikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqyl
rpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefr
taavegpfvtldmedcgynipqtdes

SCOPe Domain Coordinates for d4i0ea1:

Click to download the PDB-style file with coordinates for d4i0ea1.
(The format of our PDB-style files is described here.)

Timeline for d4i0ea1:

View in 3D
Domains from same chain:
(mouse over for more information)
d4i0ea2