SCOPe 2.05: Domain d4hypd_: 4hyp D:

Lineage for d4hypd_ (4hyp D:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
   8-stranded mixed beta-sheet; 2 layers: alpha/beta

4. Superfamily d.122.1: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (5 families)

5. Family d.122.1.2: DNA gyrase/MutL, N-terminal domain [55879] (7 proteins)

6. Protein automated matches [191126] (2 species)
   not a true protein

7. Species Escherichia coli K-12 [TaxId:83333] [226425] (3 PDB entries)

8. Domain d4hypd_: 4hyp D: [222801]
   automated match to d1kzna_
   complexed with 1a1, mg

Details for d4hypd_

PDB Entry: 4hyp, 2.6 Å

PDB Description: Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.

PDB Compounds: (D:) DNA gyrase subunit b

SCOPe Domain Sequences for d4hypd_:

Sequence, based on SEQRES records:

>d4hypd_ d.122.1.2 (D:) automated matches {Escherichia coli K-12 [TaxId: 83333]}
gldavrkrpgmyigdtddgtglhhmvfevvdnaidealaghckeiivtihadnsvsvqdd
grgiptgihpeegvsaaevimtvlhaggkfddnsykvsgglhgvgvsvvnalsqklelvi
qregkihrqiyehgvpqaplavtgetektgtmvrfwpsletftnvtefeyeilakrlrel
sflnsgvsirlrdkrdgkedhfhy

Sequence, based on observed residues (ATOM records):

>d4hypd_ d.122.1.2 (D:) automated matches {Escherichia coli K-12 [TaxId: 83333]}
gldavrkrpgmyigdtddgtglhhmvfevvdnaidealaghckeiivtihadnsvsvqdd
grgiptgivsaaevimtvlhaggkfkvsgglhgvgvsvvnalsqklelviqregkihrqi
yehgvpqaplavtgetektgtmvrfwpsletftnvtefeyeilakrlrelsflnsgvsir
lrdkrdgkedhfhy

Timeline for d4hypd_:

• d4hypd_ first appeared in SCOPe 2.03
  
• d4hypd_ appears in SCOPe 2.04
  
• d4hypd_ appears in SCOPe 2.06
  
• d4hypd_ appears in the current release, SCOPe 2.08