SCOPe 2.03: Domain d4hxma_: 4hxm A:

Lineage for d4hxma_ (4hxm A:)

1. Root: SCOPe 2.03

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.29: Bromodomain-like [47363] (15 superfamilies)
   4 helices; bundle; minor mirror variant of up-and-down topology

4. Superfamily a.29.2: Bromodomain [47370] (2 families)

5. Family a.29.2.0: automated matches [191428] (1 protein)
   not a true family

6. Protein automated matches [190615] (4 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187641] (145 PDB entries)

8. Domain d4hxma_: 4hxm A: [222775]
   automated match to d3uvya_
   complexed with 1a8

Details for d4hxma_

PDB Entry: 4hxm, 1.5 Å

PDB Description: brd4 bromodomain 1 complex with n-{3-(2-oxo-2,3-dihydro-1,3-thiazol-4-yl)-5-[(thiophen-2-ylsulfonyl)amino]phenyl}butanamide inhibitor

PDB Compounds: (A:) Bromodomain-containing protein 4

SCOPe Domain Sequences for d4hxma_:

Sequence; same for both SEQRES and ATOM records:

>d4hxma_ a.29.2.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
mnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiik
tpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkin
elpt

Timeline for d4hxma_:

• d4hxma_ is new in SCOPe 2.03-stable
  
• d4hxma_ appears in SCOPe 2.04
  
• d4hxma_ appears in the current release, SCOPe 2.08, called d4hxma1