SCOPe 2.08: Domain d4hxla1: 4hxl A:44-167

Lineage for d4hxla1 (4hxl A:44-167)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.29: Bromodomain-like [47363] (15 superfamilies)
   4 helices; bundle; minor mirror variant of up-and-down topology

4. Superfamily a.29.2: Bromodomain [47370] (2 families)

5. Family a.29.2.0: automated matches [191428] (1 protein)
   not a true family

6. Protein automated matches [190615] (15 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187641] (1052 PDB entries)

8. Domain d4hxla1: 4hxl A:44-167 [222774]
   Other proteins in same PDB: d4hxla2
   automated match to d2nxba_
   complexed with 1a9

Details for d4hxla1

PDB Entry: 4hxl, 1.52 Å

PDB Description: brd4 bromodomain 1 complex with 3-cyclohexyl-n-{3-(2-oxo-2,3-dihydro-1,3-thiazol-4-yl)-5-[(thiophen-2-ylsulfonyl)amino]phenyl}propanamide inhibitor

PDB Compounds: (A:) Bromodomain-containing protein 4

SCOPe Domain Sequences for d4hxla1:

Sequence; same for both SEQRES and ATOM records:

>d4hxla1 a.29.2.0 (A:44-167) automated matches {Human (Homo sapiens) [TaxId: 9606]}
nppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiikt
pmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkine
lpte

Timeline for d4hxla1:

• d4hxla1 first appeared in SCOPe 2.03, called d4hxla_
  
• d4hxla1 appears in SCOPe 2.07