SCOPe 2.08: Domain d4hvia_: 4hvi A:

Lineage for d4hvia_ (4hvi A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d4hvia_: 4hvi A: [222755]
   automated match to d3q32b_
   complexed with 19s

Details for d4hvia_

PDB Entry: 4hvi, 2.4 Å

PDB Description: JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((R)-1-methyl-2-oxo-2-piperidin-1-yl-ethyl)-amide

PDB Compounds: (A:) Tyrosine-protein kinase JAK3

SCOPe Domain Sequences for d4hvia_:

Sequence, based on SEQRES records:

>d4hvia_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
tifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqreiqi
lkalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrhrarldasrlllyssqic
kgmeylgsrrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvrepgqspifwy
apeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgserdvpalsrllell
eegqrlpappacpaevhelmklcwapspqdrpsfsalgpqldmlwsg

Sequence, based on observed residues (ATOM records):

>d4hvia_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
tifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqgpdqqrdfqreiqilk
alhsdfivkyrgvsylrlvmeylpsgclrdflqrhrarldasrlllyssqickgmeylgs
rrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvrepgqspifwyapeslsdn
ifsrqsdvwsfgvvlyelftycdkscspsaeflrmmvpalsrllelleegqrlpappacp
aevhelmklcwapspqdrpsfsalgpqldmlwsg

Timeline for d4hvia_:

• d4hvia_ first appeared in SCOPe 2.03
  
• d4hvia_ appears in SCOPe 2.07