SCOPe 2.06: Domain d4hlaa_: 4hla A:

Lineage for d4hlaa_ (4hla A:)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.1: Retroviral protease (retropepsin) [50631] (9 proteins)
   dimer of identical mono-domain chains, each containing (6,10) barrel

6. Protein Human immunodeficiency virus type 1 protease [50632] (9 species)

7. Species Human immunodeficiency virus type 1 (bru isolate) [TaxId:11686] [194276] (21 PDB entries)

8. Domain d4hlaa_: 4hla A: [222656]
   automated match to d1nh0a_
   complexed with 017

Details for d4hlaa_

PDB Entry: 4hla, 1.95 Å

PDB Description: Crystal structure of wild type HIV-1 protease in complex with darunavir

PDB Compounds: (A:) Protease

SCOPe Domain Sequences for d4hlaa_:

Sequence; same for both SEQRES and ATOM records:

>d4hlaa_ b.50.1.1 (A:) Human immunodeficiency virus type 1 protease {Human immunodeficiency virus type 1 (bru isolate) [TaxId: 11686]}
pqitlwqrplvtikiggqlkealldtgaddtvleemslpgrwkpkmiggiggfikvrqyd
qilieicghkaigtvlvgptpvniigrnlltqigctlnf

Timeline for d4hlaa_:

• d4hlaa_ first appeared in SCOPe 2.03
  
• d4hlaa_ appears in SCOPe 2.05
  
• d4hlaa_ appears in SCOPe 2.07
  
• d4hlaa_ appears in the current release, SCOPe 2.08