SCOPe 2.08: Domain d4h4oa2: 4h4o A:430-548

Lineage for d4h4oa2 (4h4o A:430-548)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.55: Ribonuclease H-like motif [53066] (7 superfamilies)
   3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145; strand 2 is antiparallel to the rest

4. Superfamily c.55.3: Ribonuclease H-like [53098] (18 families)
   consists of one domain of this fold

5. Family c.55.3.0: automated matches [191357] (1 protein)
   not a true family

6. Protein automated matches [190396] (40 species)
   not a true protein

7. Species Human immunodeficiency virus type 1 bh10 [TaxId:11678] [225195] (20 PDB entries)

8. Domain d4h4oa2: 4h4o A:430-548 [222385]
   Other proteins in same PDB: d4h4oa1, d4h4oa3, d4h4ob_
   automated match to d1bqna1
   complexed with 506

Details for d4h4oa2

PDB Entry: 4h4o, 2.9 Å

PDB Description: crystal structure of hiv-1 reverse transcriptase (rt) in complex with (e)-3-(3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)- 4- fluorophenoxy)-5-fluorophenyl)acrylonitrile (jlj506), a non- nucleoside inhibitor

PDB Compounds: (A:) Reverse transcriptase/ribonuclease H, Exoribonuclease H, p66 RT

SCOPe Domain Sequences for d4h4oa2:

Sequence; same for both SEQRES and ATOM records:

>d4h4oa2 c.55.3.0 (A:430-548) automated matches {Human immunodeficiency virus type 1 bh10 [TaxId: 11678]}
ekepivgaetfyvdgaanretklgkagyvtnkgrqkvvpltnttnqktelqaiylalqds
glevnivtdsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpahkgiggneqv

Timeline for d4h4oa2:

• d4h4oa2 first appeared in SCOPe 2.03
  
• d4h4oa2 appears in SCOPe 2.07