SCOPe 2.05: Domain d4h3jb_: 4h3j B:

Lineage for d4h3jb_ (4h3j B:)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (258 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d4h3jb_: 4h3j B: [222378]
   automated match to d3l5ea_
   complexed with 10w, tla

Details for d4h3jb_

PDB Entry: 4h3j, 1.6 Å

PDB Description: Structure of BACE Bound to 2-fluoro-5-(5-(2-imino-3-methyl-4-oxo-6-phenyloctahydro-1H-pyrrolo[3,4-d]pyrimidin-7a-yl)thiophen-2-yl)benzonitrile

PDB Compounds: (B:) Beta-secretase 1

SCOPe Domain Sequences for d4h3jb_:

Sequence; same for both SEQRES and ATOM records:

>d4h3jb_ b.50.1.2 (B:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
gsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrql
sstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwe
gilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmii
ggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrl
pkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsf
ritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfav
sachvhdefrtaavegpfvtldmedcgyn

Timeline for d4h3jb_:

• d4h3jb_ first appeared in SCOPe 2.03
  
• d4h3jb_ appears in SCOPe 2.04
  
• d4h3jb_ appears in SCOPe 2.06
  
• d4h3jb_ appears in the current release, SCOPe 2.08