Lineage for d4h3gb_ (4h3g B:)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2058814Fold b.50: Acid proteases [50629] (1 superfamily)
    barrel, closed; n=6, S=10, complex topology
  4. 2058815Superfamily b.50.1: Acid proteases [50630] (4 families) (S)
  5. 2060177Family b.50.1.2: Pepsin-like [50646] (11 protein domains)
    duplication: consists of two similar barrel domains
    N-terminal: barrel, partly opened; n*=6, S*=10
  6. 2060235Protein beta-secretase (memapsin) [50671] (1 species)
  7. 2060236Species Human (Homo sapiens) [TaxId:9606] [50672] (275 PDB entries)
    Uniprot P56817 58-446 ! Uniprot P56817 60-447
  8. 2060323Domain d4h3gb_: 4h3g B: [222376]
    automated match to d3l5ea_
    complexed with 10q, tla

Details for d4h3gb_

PDB Entry: 4h3g (more details), 1.85 Å

PDB Description: Structure of BACE Bound to 2-((7aR)-7a-(4-(3-cyanophenyl)thiophen-2-yl)-2-imino-3-methyl-4-oxohexahydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)nicotinonitrile
PDB Compounds: (B:) Beta-secretase 1

SCOPe Domain Sequences for d4h3gb_:

Sequence; same for both SEQRES and ATOM records: (download)

>d4h3gb_ b.50.1.2 (B:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d4h3gb_:

Click to download the PDB-style file with coordinates for d4h3gb_.
(The format of our PDB-style files is described here.)

Timeline for d4h3gb_: