Lineage for d4h3fa_ (4h3f A:)

  1. Root: SCOPe 2.04
  2. 1510239Class b: All beta proteins [48724] (176 folds)
  3. 1548217Fold b.50: Acid proteases [50629] (1 superfamily)
    barrel, closed; n=6, S=10, complex topology
  4. 1548218Superfamily b.50.1: Acid proteases [50630] (4 families) (S)
  5. 1549490Family b.50.1.2: Pepsin-like [50646] (11 proteins)
    duplication: consists of two similar barrel domains
    N-terminal: barrel, partly opened; n*=6, S*=10
  6. 1549547Protein beta-secretase (memapsin) [50671] (1 species)
  7. 1549548Species Human (Homo sapiens) [TaxId:9606] [50672] (242 PDB entries)
    Uniprot P56817 58-446 ! Uniprot P56817 60-447
  8. 1549584Domain d4h3fa_: 4h3f A: [222373]
    automated match to d3l5ea_
    complexed with 10o, tla

Details for d4h3fa_

PDB Entry: 4h3f (more details), 1.7 Å

PDB Description: Structure of BACE Bound to 3-(5-((7aR)-2-imino-6-(6-methoxypyridin-2-yl)-3-methyl-4-oxooctahydro-1H-pyrrolo[3,4-d]pyrimidin-7a-yl)thiophen-3-yl)benzonitrile
PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d4h3fa_:

Sequence; same for both SEQRES and ATOM records: (download)

>d4h3fa_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d4h3fa_:

Click to download the PDB-style file with coordinates for d4h3fa_.
(The format of our PDB-style files is described here.)

Timeline for d4h3fa_: