SCOPe 2.08: Domain d4gwga2: 4gwg A:177-469

Lineage for d4gwga2 (4gwg A:177-469)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.100: 6-phosphogluconate dehydrogenase C-terminal domain-like [48178] (1 superfamily)
   multihelical; common core is formed around two long antiparallel helices related by (pseudo) twofold symmetry

4. Superfamily a.100.1: 6-phosphogluconate dehydrogenase C-terminal domain-like [48179] (13 families)
   N-terminal domain is Rossmann-fold with a family-specific C-terminal extension

5. Family a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain [48180] (3 proteins)
   Hydroxyisobutyrate dehydrogenase domain is similar to one structural repeat in the 6-phosphogluconate dehydrogenase domain

6. Protein automated matches [227013] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [225747] (2 PDB entries)

8. Domain d4gwga2: 4gwg A:177-469 [222236]
   Other proteins in same PDB: d4gwga1
   automated match to d2pgda1
   complexed with mes

Details for d4gwga2

PDB Entry: 4gwg, 1.39 Å

PDB Description: crystal structure analysis of 6-phosphogluconate dehydrogenase apo- form

PDB Compounds: (A:) 6-phosphogluconate dehydrogenase, decarboxylating

SCOPe Domain Sequences for d4gwga2:

Sequence, based on SEQRES records:

>d4gwga2 a.100.1.1 (A:177-469) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gaghfvkmvhngieygdmqliceayhlmkdvlgmaqdemaqafedwnkteldsflieita
nilkfqdtdgkhllpkirdsagqkgtgkwtaisaleygvpvtligeavfarclsslkder
iqaskklkgpqkfqfdgdkksfledirkalyaskiisyaqgfmllrqaatefgwtlnygg
ialmwrggciirsvflgkikdafdrnpelqnlllddffksavencqdswrravstgvqag
ipmpcfttalsfydgyrhemlpasliqaqrdyfgahtyellakpgqfihtnwt

Sequence, based on observed residues (ATOM records):

>d4gwga2 a.100.1.1 (A:177-469) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gaghfvkmvhngieygdmqliceayhlmkdvlgmaqdemaqafedwnkteldsflieita
nilkfqdtdgkhllpkirdsagqkgtgkwtaisaleygvpvtligeavfarclsslkder
iqaskklkgpfqfdgdkksfledirkalyaskiisyaqgfmllrqaatefgwtlnyggia
lmwrggciirsvflgkikdafdrnpelqnlllddffksavencqdswrravstgvqagip
mpcfttalsfydgyrhemlpasliqaqrdyfgahtyellakpgqfihtnwt

Timeline for d4gwga2:

• d4gwga2 first appeared in SCOPe 2.03
  
• d4gwga2 appears in SCOPe 2.07