SCOPe 2.03: Domain d4geea_: 4gee A:

Lineage for d4geea_ (4gee A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
   8-stranded mixed beta-sheet; 2 layers: alpha/beta

4. Superfamily d.122.1: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (5 families)

5. Family d.122.1.0: automated matches [227160] (1 protein)
   not a true family

6. Protein automated matches [226867] (10 species)
   not a true protein

7. Species Enterococcus faecalis [TaxId:226185] [226590] (9 PDB entries)

8. Domain d4geea_: 4gee A: [221875]
   automated match to d1kzna_
   protein/DNA complex; complexed with 0wt, gol

Details for d4geea_

PDB Entry: 4gee, 1.7 Å

PDB Description: Pyrrolopyrimidine inhibitors of DNA gyrase B and topoisomerase IV, part I: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.

PDB Compounds: (A:) DNA gyrase subunit b

SCOPe Domain Sequences for d4geea_:

Sequence, based on SEQRES records:

>d4geea_ d.122.1.0 (A:) automated matches {Enterococcus faecalis [TaxId: 226185]}
gleavrkrpgmyigstsgeglhhlvweivdnsidealagfaksiqviiepddsitviddg
rgipvgiqaktgrpavetvftvlhaggkfggggykvsgglhgvgssvvnalstsldvrvy
kdgkvyyqeyrrgavvddlkvieetdrhgttvhfipdpeiftettvydfdklatrvrela
flnrglhisiedrregqedkkeyhyegleh

Sequence, based on observed residues (ATOM records):

>d4geea_ d.122.1.0 (A:) automated matches {Enterococcus faecalis [TaxId: 226185]}
gleavrkrpgmyigstsgeglhhlvweivdnsidealagfaksiqviiepddsitviddg
rgipvgiqaktgrpavetvftvlhgvgssvvnalstsldvrvykdgkvyyqeyrrgavvd
dlkvieetdrhgttvhfipdpeiftettvydfdklatrvrelaflnrglhisiedrregq
edkkeyhyegleh

Timeline for d4geea_:

• d4geea_ is new in SCOPe 2.03-stable
  
• d4geea_ appears in SCOPe 2.04
  
• d4geea_ appears in the current release, SCOPe 2.08, called d4geea1