SCOPe 2.03: Domain d4g34a_: 4g34 A:

Lineage for d4g34a_ (4g34 A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (18 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (314 PDB entries)

8. Domain d4g34a_: 4g34 A: [221676]
   automated match to d3o0ga_
   complexed with 924

Details for d4g34a_

PDB Entry: 4g34, 2.7 Å

PDB Description: crystal structure of gsk6924 bound to perk (r587-r1092, delete a660- t867) at 2.70 a resolution

PDB Compounds: (A:) Eukaryotic translation initiation factor 2-alpha kinase 3

SCOPe Domain Sequences for d4g34a_:

Sequence, based on SEQRES records:

>d4g34a_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gryltdfepiqclgrggfgvvfeaknkvddcnyaikrirlpnrelarekvmrevkalakl
ehpgivryfnawlekntteklqpsspkvylyiqmqlcrkenlkdwmngrctieerersvc
lhiflqiaeaveflhskglmhrdlkpsnifftmddvvkvgdfglvtamdqdeeeqtvltp
mpayarhtgqvgtklymspeqihgnsyshkvdifslglilfellypfstqmervrtltdv
rnlkfpplftqkypceyvmvqdmlspspmerpeainiienavfed

Sequence, based on observed residues (ATOM records):

>d4g34a_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gryltdfepiqclgrggfgvvfeaknkvddcnyaikrirlpnrelarekvmrevkalakl
ehpgivryfnawleknkvylyiqmqlcrkenlkdwmngrctieerersvclhiflqiaea
veflhskglmhrdlkpsnifftmddvvkvgdfglgtklymspeqihgnsyshkvdifslg
lilfellypfstqmervrtltdvrnlkfpplftqkypceyvmvqdmlspspmerpeaini
ienavfed

Timeline for d4g34a_:

• d4g34a_ is new in SCOPe 2.03-stable
  
• d4g34a_ appears in SCOPe 2.04
  
• d4g34a_ appears in the current release, SCOPe 2.08, called d4g34a1