SCOPe 2.05: Domain d4ftla_: 4ftl A:

Lineage for d4ftla_ (4ftl A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cell cycle checkpoint kinase chk1 [64404] (1 species)
   CaMK group; CAMKL subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [64405] (61 PDB entries)

8. Domain d4ftla_: 4ftl A: [221515]
   automated match to d4ftca_
   complexed with h0k, ipa, so4

Details for d4ftla_

PDB Entry: 4ftl, 2.5 Å

PDB Description: crystal structure of the chk1

PDB Compounds: (A:) Serine/threonine-protein kinase Chk1

SCOPe Domain Sequences for d4ftla_:

Sequence, based on SEQRES records:

>d4ftla_ d.144.1.7 (A:) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
vpfvedwdlvqtlgegaygevqlavnrvteeavavkivdmkravdcpenikkeicinkml
nhenvvkfyghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylh
gigithrdikpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrr
efhaepvdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplall
hkilvenpsaritipdikkdrwynkplkkgakrprvts

Sequence, based on observed residues (ATOM records):

>d4ftla_ d.144.1.7 (A:) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
vpfvedwdlvqtlgevqlavnrvteeavavkivnikkeicinkmlnhenvvkfyghrreg
niqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgigithrdikpenll
lderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefhaepvdvwscgiv
ltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilvenpsaritip
dikkdrwynkplkkgakrprvts

Timeline for d4ftla_:

• d4ftla_ first appeared in SCOPe 2.03
  
• d4ftla_ appears in SCOPe 2.04
  
• d4ftla_ appears in SCOPe 2.06
  
• d4ftla_ appears in the current release, SCOPe 2.08