SCOPe 2.08: Domain d4fk6a_: 4fk6 A:

Lineage for d4fk6a_ (4fk6 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d4fk6a_: 4fk6 A: [221242]
   automated match to d3bhhd_
   complexed with 0uj

Details for d4fk6a_

PDB Entry: 4fk6, 2.2 Å

PDB Description: JAK1 kinase (JH1 domain) in complex with compound 72

PDB Compounds: (A:) Tyrosine-protein kinase JAK1

SCOPe Domain Sequences for d4fk6a_:

Sequence, based on SEQRES records:

>d4fk6a_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
tevdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkpesggnhiadl
kkeieilrnlyhenivkykgictedggngiklimeflpsgslkeylpknknkinlkqqlk
yavqickgmdylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdkeyytvkddrd
spvfwyapeclmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmigpthgqmtvt
rlvntlkegkrlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeallk

Sequence, based on observed residues (ATOM records):

>d4fk6a_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
tevdpthfekrflkrirdlgefgkvelcrydpegdntgeqvavkslkpenhiadlkkeie
ilrnlyhenivkykgictedggngiklimeflpsgslkeylpknknkinlkqqlkyavqi
ckgmdylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdkeyytvkddrdspvfw
yapeclmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmigpthgqmtvtrlvnt
lkegkrlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeallk

Timeline for d4fk6a_:

• d4fk6a_ first appeared in SCOPe 2.03
  
• d4fk6a_ appears in SCOPe 2.07