SCOPe 2.08: Domain d4fi8b_: 4fi8 B:

Lineage for d4fi8b_ (4fi8 B:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.3: Prealbumin-like [49451] (8 superfamilies)
   sandwich; 7 strands in 2 sheets, greek-key
   variations: some members have additional 1-2 strands to common fold

4. Superfamily b.3.4: Transthyretin (synonym: prealbumin) [49472] (2 families)

5. Family b.3.4.1: Transthyretin (synonym: prealbumin) [49473] (2 proteins)
   automatically mapped to Pfam PF00576

6. Protein Transthyretin (synonym: prealbumin) [49474] (5 species)
   sandwich; 8 strands in 2 sheets

7. Species Human (Homo sapiens) [TaxId:9606] [49475] (322 PDB entries)
   Uniprot P02766 31-143

8. Domain d4fi8b_: 4fi8 B: [221220]
   automated match to d1f41a_
   complexed with 0uc

Details for d4fi8b_

PDB Entry: 4fi8, 1.22 Å

PDB Description: kinetic stabilization of transthyretin through covalent modification of k15 by 4-bromo-3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4- oxadiazol-2-yl)-benzenesulfonamide

PDB Compounds: (B:) Transthyretin

SCOPe Domain Sequences for d4fi8b_:

Sequence; same for both SEQRES and ATOM records:

>d4fi8b_ b.3.4.1 (B:) Transthyretin (synonym: prealbumin) {Human (Homo sapiens) [TaxId: 9606]}
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispfhehaevvftandsgprrytiaallspysysttavvtn

Timeline for d4fi8b_:

• d4fi8b_ first appeared in SCOPe 2.03
  
• d4fi8b_ appears in SCOPe 2.07