Lineage for d4ewqa_ (4ewq A:)

  1. Root: SCOPe 2.06
  2. 2170735Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2218047Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2218048Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2218179Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2220075Protein MAP kinase p38 [56129] (2 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  7. 2220076Species Human (Homo sapiens) [TaxId:9606] [56130] (185 PDB entries)
  8. 2220105Domain d4ewqa_: 4ewq A: [220899]
    automated match to d2xrwa_
    complexed with act, bme, cl, gg5, gol, mwl, peg, zn

Details for d4ewqa_

PDB Entry: 4ewq (more details), 2.1 Å

PDB Description: human p38 alpha mapk in complex with a pyridazine based inhibitor
PDB Compounds: (A:) Mitogen-activated protein kinase 14

SCOPe Domain Sequences for d4ewqa_:

Sequence, based on SEQRES records: (download)

>d4ewqa_ d.144.1.7 (A:) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
rptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsiih
akrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltd
dhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtgyva
trwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpga
ellkkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqala
hayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvpppl

Sequence, based on observed residues (ATOM records): (download)

>d4ewqa_ d.144.1.7 (A:) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
rptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsiih
akrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltd
dhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfarhtddemtgyvatr
wyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgael
lkkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqalaha
yfaqyhdpddepvadpydqsfesrdllidewksltydevisfvpppl

SCOPe Domain Coordinates for d4ewqa_:

Click to download the PDB-style file with coordinates for d4ewqa_.
(The format of our PDB-style files is described here.)

Timeline for d4ewqa_: