SCOPe 2.08: Domain d4eqca1: 4eqc A:249-541

Lineage for d4eqca1 (4eqc A:249-541)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein pak1 [56146] (1 species)
   OPK group; PAK/STE20 subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56147] (19 PDB entries)

8. Domain d4eqca1: 4eqc A:249-541 [220773]
   Other proteins in same PDB: d4eqca2
   automated match to d3q4za_
   complexed with cl, xr1

Details for d4eqca1

PDB Entry: 4eqc, 2.01 Å

PDB Description: Crystal structure of PAK1 kinase domain in complex with FRAX597 inhibitor

PDB Compounds: (A:) Serine/threonine-protein kinase PAK 1

SCOPe Domain Sequences for d4eqca1:

Sequence; same for both SEQRES and ATOM records:

>d4eqca1 d.144.1.7 (A:249-541) pak1 {Human (Homo sapiens) [TaxId: 9606]}
sdeeileklrsivsvgdpkkkytrfekigqgasgtvytamdvatgqevairqmnlqqqpk
keliineilvmrenknpnivnyldsylvgdelwvvmeylaggsltdvvtetcmdegqiaa
vcreclqaleflhsnqvihrdiksdnillgmdgsvkltdfgfcaqitpeqskrstmvgtp
ywmapevvtrkaygpkvdiwslgimaiemiegeppylnenplralyliatngtpelqnpe
klsaifrdflnrclemdvekrgsakellqhqflkiakplssltpliaaakeat

Timeline for d4eqca1:

• d4eqca1 first appeared in SCOPe 2.03, called d4eqca_
  
• d4eqca1 appears in SCOPe 2.07