SCOPe 2.03: Domain d4eola_: 4eol A:

Lineage for d4eola_ (4eol A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (335 PDB entries)
   Uniprot P24941

8. Domain d4eola_: 4eol A: [220759]
   Other proteins in same PDB: d4eolb1, d4eolb2, d4eold1, d4eold2
   automated match to d4eokc_
   complexed with 1ro, mg, sgm

Details for d4eola_

PDB Entry: 4eol, 2.4 Å

PDB Description: thr 160 phosphorylated cdk2 h84s, q85m, k89d - human cyclin a3 complex with the inhibitor ro3306

PDB Compounds: (A:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d4eola_:

Sequence, based on SEQRES records:

>d4eola_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
smenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkeln
hpnivklldvihtenklylvfeflsmdlkdfmdasaltgiplpliksylfqllqglafch
shrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgcky
ystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykps
fpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlr

Sequence, based on observed residues (ATOM records):

>d4eola_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
smenfqkvekigegtygvvykarnkltgevvalkkirletegvpstaireisllkelnhp
nivklldvihtenklylvfeflsmdlkdfmdasltgiplpliksylfqllqglafchshr
vlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyyst
avdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpk
warqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlr

Timeline for d4eola_:

• d4eola_ is new in SCOPe 2.03-stable
  
• d4eola_ appears in SCOPe 2.04
  
• d4eola_ appears in the current release, SCOPe 2.08, called d4eola1