SCOPe 2.08: Domain d4eb4b_: 4eb4 B:

Lineage for d4eb4b_ (4eb4 B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein automated matches [190469] (17 species)
   not a true protein

7. Species Mouse (Mus musculus) [TaxId:10090] [225826] (11 PDB entries)

8. Domain d4eb4b_: 4eb4 B: [220396]
   automated match to d3ed7a_
   complexed with d16, dtt, gol, mes, so4, ump

Details for d4eb4b_

PDB Entry: 4eb4, 1.74 Å

PDB Description: crystal structure of mouse thymidylate synthase in ternary complex with dump and tomudex

PDB Compounds: (B:) Thymidylate synthase

SCOPe Domain Sequences for d4eb4b_:

Sequence, based on SEQRES records:

>d4eb4b_ d.117.1.1 (B:) automated matches {Mouse (Mus musculus) [TaxId: 10090]}
mlvvgselqsdaqqlsaeaprhgelqylrqvehilrcgfkkedrtgtgtlsvfgmqarys
lrdefpllttkrvfwkgvleellwfikgstnakelsskgvriwdangsrdfldslgfsar
qegdlgpvygfqwrhfgaeykdmdsdysgqgvdqlqkvidtiktnpddrriimcawnpkd
lplmalppchalcqfyvvngelscqlyqrsgdmglgvpfniasyalltymiahitglqpg
dfvhtlgdahiylnhieplkiqlqreprpfpklkilrkvetiddfkvedfqiegynphpt
ikmemav

Sequence, based on observed residues (ATOM records):

>d4eb4b_ d.117.1.1 (B:) automated matches {Mouse (Mus musculus) [TaxId: 10090]}
mlvvgselqsdaqprhgelqylrqvehilrcgfkkedrtgtgtlsvfgmqaryslrdefp
llttkrvfwkgvleellwfikgstnakelsskgvriwdangsrdfldslgfsarqegdlg
pvygfqwrhfgaeykdmdsdysgqgvdqlqkvidtiktnpddrriimcawnpkdlplmal
ppchalcqfyvvngelscqlyqrsgdmglgvpfniasyalltymiahitglqpgdfvhtl
gdahiylnhieplkiqlqreprpfpklkilrkvetiddfkvedfqiegynphptikmema
v

Timeline for d4eb4b_:

• d4eb4b_ first appeared in SCOPe 2.03
  
• d4eb4b_ appears in SCOPe 2.07