SCOPe 2.08: Domain d4e6db_: 4e6d B:

Lineage for d4e6db_ (4e6d B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d4e6db_: 4e6d B: [220322]
   automated match to d4e6qb_
   complexed with 0nu, gol; mutant

Details for d4e6db_

PDB Entry: 4e6d, 2.22 Å

PDB Description: JAK2 kinase (JH1 domain) triple mutant in complex with compound 7

PDB Compounds: (B:) Tyrosine-protein kinase JAK2

SCOPe Domain Sequences for d4e6db_:

Sequence, based on SEQRES records:

>d4e6db_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dptqfeerhlkflrqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdferei
eilkslqhdnivkykgvcysagrrnlklimeflpygslreylqkhkeridhikllqytsq
ickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespif
wyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhli
ellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag

Sequence, based on observed residues (ATOM records):

>d4e6db_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dptqfeerhlkflrqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdferei
eilkslqhdnivkykgvcynlklimeflpygslreylqkhkeridhikllqytsqickgm
eylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifwyape
slteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhliellkn
ngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag

Timeline for d4e6db_:

• d4e6db_ first appeared in SCOPe 2.03
  
• d4e6db_ appears in SCOPe 2.07