SCOPe 2.08: Domain d4e4ld_: 4e4l D:

Lineage for d4e4ld_ (4e4l D:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d4e4ld_: 4e4l D: [220302]
   automated match to d3bhhd_
   complexed with 0nh

Details for d4e4ld_

PDB Entry: 4e4l, 2 Å

PDB Description: JAK1 kinase (JH1 domain) in complex with compound 30

PDB Compounds: (D:) Tyrosine-protein kinase JAK1

SCOPe Domain Sequences for d4e4ld_:

Sequence, based on SEQRES records:

>d4e4ld_ d.144.1.0 (D:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
evdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkpesggnhiadlk
keieilrnlyhenivkykgictedggngiklimeflpsgslkeylpknknkinlkqqlky
avqickgmdylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdkeyytvkddrds
pvfwyapeclmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmigpthgqmtvtr
lvntlkegkrlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeallk

Sequence, based on observed residues (ATOM records):

>d4e4ld_ d.144.1.0 (D:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
evdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkhiadlkkeieil
rnlyhenivkykgictggngiklimeflpsgslkeylpknknkinlkqqlkyavqickgm
dylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdkeyytvkddrdspvfwyape
clmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmigpthgqmtvtrlvntlkeg
krlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeallk

Timeline for d4e4ld_:

• d4e4ld_ first appeared in SCOPe 2.03
  
• d4e4ld_ appears in SCOPe 2.07