SCOPe 2.08: Domain d4dceb_: 4dce B:

Lineage for d4dceb_ (4dce B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d4dceb_: 4dce B: [219682]
   automated match to d2i0ya_
   complexed with 0jf

Details for d4dceb_

PDB Entry: 4dce, 2.03 Å

PDB Description: crystal structure of human anaplastic lymphoma kinase in complex with a piperidine-carboxamide inhibitor

PDB Compounds: (B:) ALK tyrosine kinase receptor

SCOPe Domain Sequences for d4dceb_:

Sequence, based on SEQRES records:

>d4dceb_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
pnysfagktssisdlkevprknitlirglghgafgevyegqvsgmpndpsplqvavktlp
evcseqdeldflmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretrp
rpsqpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfgm
ardiyrasyyrkggcamlpvkwmppeafmegiftsktdtwsfgvllweifslgympypsk
snqevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvi
ntalpieyg

Sequence, based on observed residues (ATOM records):

>d4dceb_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
pnysfagktssisdlkevprknitlirglghevyegqvssplqvavktlpevcseqdeld
flmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretrprpsqpsslam
ldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfgcamlpvkwmpp
eafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsggrmdppkncpgpv
yrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpieyg

Timeline for d4dceb_:

• d4dceb_ first appeared in SCOPe 2.03
  
• d4dceb_ appears in SCOPe 2.07