SCOPe 2.03: Domain d4c02a_: 4c02 A:

Lineage for d4c02a_ (4c02 A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (11 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (418 PDB entries)

8. Domain d4c02a_: 4c02 A: [219561]
   Other proteins in same PDB: d4c02b_
   automated match to d3h9ra_
   complexed with edo, flc, tak

Details for d4c02a_

PDB Entry: 4c02, 2.17 Å

PDB Description: crystal structure of human acvr1 (alk2) in complex with fkbp12.6 and dorsomorphin

PDB Compounds: (A:) Activin receptor type-1

SCOPe Domain Sequences for d4c02a_:

Sequence, based on SEQRES records:

>d4c02a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
stladlldhsctsgsgsglpflvqrtvarqitllecvgkgrygevwrgswqgenvavkif
ssrdekswfretelyntvmlrhenilgfiasdmtsrhsstqlwlithyhemgslydylql
ttldtvsclrivlsiasglahlhieifgtqgkpaiahrdlksknilvkkngqcciadlgl
avmhsqstnqldvgnnprvgtkrymapevldetiqvdcfdsykrvdiwafglvlwevarr
mvsngivedykppfydvvpndpsfedmrkvvcvdqqrpnipnrwfsdptltslaklmkec
wyqnpsarltalrikktltkid

Sequence, based on observed residues (ATOM records):

>d4c02a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
stladlldsgsgsglpflvqrtvarqitllecvgkgrygevwrgswqgenvavkifssrd
ekswfretelyntvmlrhenilgfiasdmtsrstqlwlithyhemgslydylqlttldtv
sclrivlsiasglahlhieifgtqgkpaiahrdlksknilvkkngqcciadlglavmhsq
stnqldvprvgtkrymapevldetiqvdcfdsykrvdiwafglvlwevarrmvsngived
ykppfydvvpndpsfedmrkvvcvdqqrpnipnrwfsdptltslaklmkecwyqnpsarl
talrikktltkid

Timeline for d4c02a_:

• d4c02a_ is new in SCOPe 2.03-stable
  
• d4c02a_ appears in SCOPe 2.04
  
• d4c02a_ appears in the current release, SCOPe 2.08