SCOPe 2.08: Domain d4bvhc_: 4bvh C:

Lineage for d4bvhc_ (4bvh C:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.0: automated matches [191352] (1 protein)
   not a true family

6. Protein automated matches [190312] (14 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [224883] (17 PDB entries)

8. Domain d4bvhc_: 4bvh C: [219560]
   automated match to d1j8fc_
   complexed with ar6, cl, edo, gol, na, oad, ocz, zn

Details for d4bvhc_

PDB Entry: 4bvh, 1.9 Å

PDB Description: crystal structure of human sirt3 in complex with the inhibitor ex-527 and 2'-o-acetyl-adp-ribose

PDB Compounds: (C:) NAD-dependent protein deacetylase sirtuin-3, mitochondrial

SCOPe Domain Sequences for d4bvhc_:

Sequence, based on SEQRES records:

>d4bvhc_ c.31.1.0 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gklslqdvaeliraracqrvvvmvgagistpsgipdfrspgsglysnlqqydlpypeaif
elpfffhnpkpfftlakelypgnykpnvthyflrllhdkglllrlytqnidglervsgip
asklveahgtfasatctvcqrpfpgediradvmadrvprcpvctgvvkpdivffgeplpq
rfllhvvdfpmadlllilgtslevepfaslteavrssvprllinrdlvgplawhprsrdv
aqlgdvvhgveslvellgwteemrdlvqretgk

Sequence, based on observed residues (ATOM records):

>d4bvhc_ c.31.1.0 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gklslqdvaeliraracqrvvvmvgagistpsgipdfrspgsglysnlqlpypeaifelp
fffhnpkpfftlakelypgnykpnvthyflrllhdkglllrlytqnidglervsgipask
lveahgtfasatctvcqrpfpgediradvmadrvprcpvctgvvkpdivffgeplpqrfl
lhvvdfpmadlllilgtslevepfaslteavrssvprllinrdlvgplawhprsrdvaql
gdvvhgveslvellgwteemrdlvqretgk

Timeline for d4bvhc_:

• d4bvhc_ first appeared in SCOPe 2.03
  
• d4bvhc_ appears in SCOPe 2.07