SCOPe 2.06: Domain d4bcoc1: 4bco C:1-296

Lineage for d4bcoc1 (4bco C:1-296)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (374 PDB entries)
   Uniprot P24941

8. Domain d4bcoc1: 4bco C:1-296 [219435]
   Other proteins in same PDB: d4bcoa2, d4bcob1, d4bcob2, d4bcoc2, d4bcod1, d4bcod2
   automated match to d3bhta_
   complexed with sgm, so4, t6q

Details for d4bcoc1

PDB Entry: 4bco, 2.05 Å

PDB Description: Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor

PDB Compounds: (C:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d4bcoc1:

Sequence, based on SEQRES records:

>d4bcoc1 d.144.1.7 (C:1-296) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl

Sequence, based on observed residues (ATOM records):

>d4bcoc1 d.144.1.7 (C:1-296) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtskvvppldedgrsllsqml
hydpnkrisakaalahpffqdvtkpvphl

Timeline for d4bcoc1:

• d4bcoc1 first appeared in SCOPe 2.03, called d4bcoc_
  
• d4bcoc1 was called d4bcoc_ in SCOPe 2.05
  
• d4bcoc1 appears in SCOPe 2.07
  
• d4bcoc1 appears in the current release, SCOPe 2.08