SCOPe 2.05: Domain d4bcoc_: 4bco C:

Lineage for d4bcoc_ (4bco C:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (348 PDB entries)
   Uniprot P24941

8. Domain d4bcoc_: 4bco C: [219435]
   Other proteins in same PDB: d4bcob1, d4bcob2, d4bcod1, d4bcod2
   automated match to d3bhta_
   complexed with sgm, so4, t6q

Details for d4bcoc_

PDB Entry: 4bco, 2.05 Å

PDB Description: Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor

PDB Compounds: (C:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d4bcoc_:

Sequence, based on SEQRES records:

>d4bcoc_ d.144.1.7 (C:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
smenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkeln
hpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafch
shrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgcky
ystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykps
fpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl

Sequence, based on observed residues (ATOM records):

>d4bcoc_ d.144.1.7 (C:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
smenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkeln
hpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafch
shrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgcky
ystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtskvvppldedgrsllsqm
lhydpnkrisakaalahpffqdvtkpvphl

Timeline for d4bcoc_:

• d4bcoc_ first appeared in SCOPe 2.03
  
• d4bcoc_ appears in SCOPe 2.04
  
• d4bcoc_ is called d4bcoc1 in SCOPe 2.06
  
• d4bcoc_ appears in the current release, SCOPe 2.08, called d4bcoc1