SCOPe 2.05: Domain d4bcha_: 4bch A:

Lineage for d4bcha_ (4bch A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (12 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (553 PDB entries)

8. Domain d4bcha_: 4bch A: [219417]
   Other proteins in same PDB: d4bchb1, d4bchb2
   automated match to d3my1a_
   complexed with gol, t7z

Details for d4bcha_

PDB Entry: 4bch, 2.96 Å

PDB Description: structure of cdk9 in complex with cyclin t and a 2-amino-4-heteroaryl- pyrimidine inhibitor

PDB Compounds: (A:) Cyclin-dependent kinase 9

SCOPe Domain Sequences for d4bcha_:

Sequence, based on SEQRES records:

>d4bcha_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
svecpfcdevskyeklakigqgtfgevfkarhrktgqkvalkkvlmenekegfpitalre
ikilqllkhenvvnlieicrtkaspynrckgsiylvfdfcehdlagllsnvlvkftlsei
krvmqmllnglyyihrnkilhrdmkaanvlitrdgvlkladfglarafslaknsqpnryt
nrvvtlwyrppelllgerdygppidlwgagcimaemwtrspimqgnteqhqlalisqlcg
sitpevwpnvdnyelyeklelvkgqkrkvkdrlkayvrdpyaldlidkllvldpaqrids
ddalnhdffwsdpmpsdlkgm

Sequence, based on observed residues (ATOM records):

>d4bcha_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
svecpfcdevskyeklakigqgtfgevfkarhrktgqkvalkkvlmenekegfpitalre
ikilqllkhenvvnlieicrtkagsiylvfdfcehdlagllsnvlvkftlseikrvmqml
lnglyyihrnkilhrdmkaanvlitrdgvlkladfglarafslpnrytnrvvtlwyrppe
lllgerdygppidlwgagcimaemwtrspimqgnteqhqlalisqlcgsitpevwpnvdn
yelyeklelvkgqkrkvkdrlkayvrdpyaldlidkllvldpaqridsddalnhdffwsd
pmpsdlkgm

Timeline for d4bcha_:

• d4bcha_ first appeared in SCOPe 2.03
  
• d4bcha_ appears in SCOPe 2.04
  
• d4bcha_ appears in SCOPe 2.06
  
• d4bcha_ appears in the current release, SCOPe 2.08