Lineage for d4bb5a_ (4bb5 A:)

  1. Root: SCOPe 2.04
  2. 1565955Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 1576363Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 1576364Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 1576689Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 1577849Protein automated matches [190085] (43 species)
    not a true protein
  7. 1578002Species Human (Homo sapiens) [TaxId:9606] [186828] (10 PDB entries)
  8. 1578008Domain d4bb5a_: 4bb5 A: [219399]
    automated match to d3dwfc1
    complexed with hd2, nap

Details for d4bb5a_

PDB Entry: 4bb5 (more details), 2.2 Å

PDB Description: Free-Wilson and Structural Approaches to Co-optimising Human and Rodent Isoform Potency for 11b-Hydroxysteroid Dehydrogenase Type 1 11b-HSD1 Inhibitors
PDB Compounds: (A:) Corticosteroid 11-beta-dehydrogenase isozyme 1

SCOPe Domain Sequences for d4bb5a_:

Sequence; same for both SEQRES and ATOM records: (download)

>d4bb5a_ c.2.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d4bb5a_:

Click to download the PDB-style file with coordinates for d4bb5a_.
(The format of our PDB-style files is described here.)

Timeline for d4bb5a_: