SCOPe 2.06: Domain d4b70a_: 4b70 A:

Lineage for d4b70a_ (4b70 A:)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (281 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d4b70a_: 4b70 A: [219346]
   automated match to d1fkna_
   complexed with wm9

Details for d4b70a_

PDB Entry: 4b70, 1.6 Å

PDB Description: Aminoimidazoles as BACE-1 Inhibitors: From De Novo Design to Ab- lowering in Brain

PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d4b70a_:

Sequence, based on SEQRES records:

>d4b70a_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
vemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlsst
yrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegil
glayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmiiggi
dhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkk
vfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfrit
ilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsac
hvhdefrtaavegpfvtldmedcgy

Sequence, based on observed residues (ATOM records):

>d4b70a_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
vemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlsst
yrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegil
glayaeiarpddslepffdslvkqthvpnlfslqlcgaggsmiiggidhslytgslwytp
irrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksikaas
stekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqylrpvedv
atsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrtaaveg
pfvtldmedcgy

Timeline for d4b70a_:

• d4b70a_ first appeared in SCOPe 2.03
  
• d4b70a_ appears in SCOPe 2.05
  
• d4b70a_ appears in SCOPe 2.07
  
• d4b70a_ appears in the current release, SCOPe 2.08, called d4b70a1