SCOPe 2.08: Domain d4b1ea1: 4b1e A:1-384

Lineage for d4b1ea1 (4b1e A:1-384)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (329 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d4b1ea1: 4b1e A:1-384 [219250]
   Other proteins in same PDB: d4b1ea2
   automated match to d4b1da_
   complexed with 6t6

Details for d4b1ea1

PDB Entry: 4b1e, 1.95 Å

PDB Description: new aminoimidazoles as bace-1 inhibitors: from rational design to ab- lowering in brain

PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d4b1ea1:

Sequence, based on SEQRES records:

>d4b1ea1 b.50.1.2 (A:1-384) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
emvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlssty
rdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegilg
layaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmiiggid
hslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkv
feaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfriti
lpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsach
vhdefrtaavegpfvtldmedcgy

Sequence, based on observed residues (ATOM records):

>d4b1ea1 b.50.1.2 (A:1-384) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
emvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlssty
rdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegilg
layaeiarpddslepffdslvkqthvpnlfslqlcgaggsmiiggidhslytgslwytpi
rrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksikaass
tekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqylrpvedva
tsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrtaavegp
fvtldmedcgy

Timeline for d4b1ea1:

• d4b1ea1 first appeared in SCOPe 2.03, called d4b1ea_
  
• d4b1ea1 was called d4b1ea_ in SCOPe 2.07