SCOPe 2.03: Domain d4aw1a_: 4aw1 A:

Lineage for d4aw1a_ (4aw1 A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (18 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (314 PDB entries)

8. Domain d4aw1a_: 4aw1 A: [219178]
   automated match to d4eopc_
   complexed with 21o, atp, cl, dms, mn, na

Details for d4aw1a_

PDB Entry: 4aw1, 1.68 Å

PDB Description: Human PDK1 Kinase Domain in Complex with Allosteric Compound PS210 Bound to the PIF-Pocket

PDB Compounds: (A:) 3-phosphoinositide-dependent protein kinase 1

SCOPe Domain Sequences for d4aw1a_:

Sequence, based on SEQRES records:

>d4aw1a_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
qhaqpppqprkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvp
yvtrerdvmsrldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfy
taeivsaleylhgkgiihrdlkpenillnedmhiqitdfgtakvlspeskqaransfvgt
aqyvspellteksackssdlwalgciiyqlvaglppfragneglifakiikleydfpekf
fpkardlvekllvldatkrlgceemegygplkahpffesvtwenlhqqtppklt

Sequence, based on observed residues (ATOM records):

>d4aw1a_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
qhaqppprkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyv
trerdvmsrldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfyta
eivsaleylhgkgiihrdlkpenillnedmhiqitdfgtakvlsaransfvgtaqyvspe
llteksackssdlwalgciiyqlvaglppfragneglifakiikleydfpekffpkardl
vekllvldatkrlgceemegygplkahpffesvtwenlhqqtppklt

Timeline for d4aw1a_:

• d4aw1a_ is new in SCOPe 2.03-stable
  
• d4aw1a_ appears in SCOPe 2.04
  
• d4aw1a_ appears in the current release, SCOPe 2.08