SCOPe 2.08: Domain d4ai8a_: 4ai8 A:

Lineage for d4ai8a_ (4ai8 A:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.82: Double-stranded beta-helix [51181] (7 superfamilies)
   one turn of helix is made by two pairs of antiparallel strands linked with short turns
   has appearance of a sandwich of distinct architecture and jelly-roll topology

4. Superfamily b.82.2: Clavaminate synthase-like [51197] (16 families)
   Iron and ketoglutarate-dependent enzymes; elaborated version of this common fold

5. Family b.82.2.6: Hypoxia-inducible factor HIF ihhibitor (FIH1) [82194] (1 protein)

6. Protein Hypoxia-inducible factor HIF ihhibitor (FIH1) [82195] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [82196] (38 PDB entries)

8. Domain d4ai8a_: 4ai8 A: [218892]
   automated match to d2y0ia_
   complexed with dza, gol, so4, zn

Details for d4ai8a_

PDB Entry: 4ai8, 2.4 Å

PDB Description: factor inhibiting hif-1 alpha in complex with daminozide

PDB Compounds: (A:) Hypoxia-inducible factor 1-alpha inhibitor

SCOPe Domain Sequences for d4ai8a_:

Sequence; same for both SEQRES and ATOM records:

>d4ai8a_ b.82.2.6 (A:) Hypoxia-inducible factor HIF ihhibitor (FIH1) {Human (Homo sapiens) [TaxId: 9606]}
sgsgepreeagalgpawdesqlrsysfptrpiprlsqsdpraeelieneepvvltdtnlv
ypalkwdleylqenigngdfsvysasthkflyydekkmanfqnfkprsnreemkfhefve
klqdiqqrggeerlylqqtlndtvgrkivmdflgfnwnwinkqqgkrgwgqltsnlllig
megnvtpahydeqqnffaqikgykrcilfppdqfeclypypvhhpcdrqsqvdfdnpdye
rfpnfqnvvgyetvvgpgdvlyipmywwhhiesllnggititvnfwykgaptpkrieypl
kahqkvaimrniekmlgealgnpqevgpllntmikgryn

Timeline for d4ai8a_:

• d4ai8a_ first appeared in SCOPe 2.03
  
• d4ai8a_ appears in SCOPe 2.07