SCOPe 2.05: Domain d3zwsa_: 3zws A:

Lineage for d3zwsa_ (3zws A:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.4: FMN-linked oxidoreductases [51395] (2 families)

5. Family c.1.4.1: FMN-linked oxidoreductases [51396] (19 proteins)

6. Protein Dihydroorotate dehydrogenase [51397] (8 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51400] (30 PDB entries)

8. Domain d3zwsa_: 3zws A: [218549]
   automated match to d1d3ga_
   complexed with act, avq, cl, fmn, oro, so4

Details for d3zwsa_

PDB Entry: 3zws, 1.6 Å

PDB Description: Structure of Human Dihydroorotate Dehydrogenase with a Bound Inhibitor

PDB Compounds: (A:) Dihydroorotate dehydrogenase (quinone), mitochondrial

SCOPe Domain Sequences for d3zwsa_:

Sequence, based on SEQRES records:

>d3zwsa_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
hlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrnpvgiaagfdk
hgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshglsvvehr
lrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnvsspntag
lrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvkelgidgl
ivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvggvssgq
dalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadhrr

Sequence, based on observed residues (ATOM records):

>d3zwsa_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
hlmptlqglldpesahrlavrftslgllarfqdsdmlevrvlghkfrnpvgiaagfdkhg
eavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshglsvvehrlr
arqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnvsspntaglr
slqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvkelgidgliv
tnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvggvssgqda
lekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadhrr

Timeline for d3zwsa_:

• d3zwsa_ first appeared in SCOPe 2.03
  
• d3zwsa_ appears in SCOPe 2.04
  
• d3zwsa_ appears in SCOPe 2.06
  
• d3zwsa_ appears in the current release, SCOPe 2.08