SCOPe 2.05: Domain d3zksa_: 3zks A:

Lineage for d3zksa_ (3zks A:)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.0: automated matches [191552] (1 protein)
   not a true family

6. Protein automated matches [190954] (9 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [193159] (12 PDB entries)

8. Domain d3zksa_: 3zks A: [218306]
   Other proteins in same PDB: d3zksd_
   automated match to d4belb_
   complexed with wzv

Details for d3zksa_

PDB Entry: 3zks, 2.11 Å

PDB Description: bace2 xaperone complex with inhibitor

PDB Compounds: (A:) Beta-secretase 2

SCOPe Domain Sequences for d3zksa_:

Sequence, based on SEQRES records:

>d3zksa_ b.50.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
anflamvdnlqgdsgrgyylemligtppqklqilvdtgssnfavagtphsyidtyfdter
sstyrskgfdvtvkytqgswtgfvgedlvtipkgfntsflvniatifesenfflpgikwn
gilglayatlakpsssletffdslvtqanipnvfsmqmcgaglpvagsgtnggslvlggi
epslykgdiwytpikeewyyqieilkleiggqslnldcreynadkaivdsgttllrlpqk
vfdavveavaraslipefsdgfwtgsqlacwtnsetpwsyfpkisiylrdenssrsfrit
ilpqlyiqpmmgaglnyecyrfgispstnalvigatvmegfyvifdraqkrvgfaaspca
eiagaavseisgpfstedvasncvp

Sequence, based on observed residues (ATOM records):

>d3zksa_ b.50.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
anflamvdnlqggyylemligtppqklqilvdtgssnfavagtphsyidtyfdterssty
rskgfdvtvkytqgswtgfvgedlvtipkgfntsflvniatifesenfflpgikwngilg
layatlakpsssletffdslvtqanipnvfsmqmcgggslvlggiepslykgdiwytpik
eewyyqieilkleiggqslnldcreynadkaivdsgttllrlpqkvfdavveavarasli
pefsdgfwtgsqlacwtpwsyfpkisiylrdenssrsfritilpqlyiqpmyecyrfgis
pstnalvigatvmegfyvifdraqkrvgfaaspcaeiagaavseisgpfstedvasncvp

Timeline for d3zksa_:

• d3zksa_ first appeared in SCOPe 2.03
  
• d3zksa_ appears in SCOPe 2.04
  
• d3zksa_ appears in SCOPe 2.06
  
• d3zksa_ appears in the current release, SCOPe 2.08