SCOPe 2.06: Domain d3zkib_: 3zki B:

Lineage for d3zkib_ (3zki B:)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.0: automated matches [191552] (1 protein)
   not a true family

6. Protein automated matches [190954] (11 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [193159] (12 PDB entries)

8. Domain d3zkib_: 3zki B: [218296]
   automated match to d3zlqb_
   complexed with wzv; mutant

Details for d3zkib_

PDB Entry: 3zki, 2.4 Å

PDB Description: bace2 mutant structure with ligand

PDB Compounds: (B:) Beta-secretase 2

SCOPe Domain Sequences for d3zkib_:

Sequence, based on SEQRES records:

>d3zkib_ b.50.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lamvdnlqgdsgrgyylemligtppqklqilvdtgssnfavagtphsyidtyfdtersst
yrskgfdvtvkytqgswtgfvgedlvtipkgfntsflvniatifesenfflpgikwngil
glayatlakpsssletffdslvtqanipnvfsmqmcgaglpvagsgtnggslvlggieps
lykgdiwytpikeewyyqieilkleiggqslnldcreynadkaivdsgttllrlpqkvfd
avveavaraslipafsdgfwtgsqlacwtnsetpwsyfpkisiylrdenssrsfritilp
qlyiqpmmgaglnyecyrfgispstnalvigatvmegfyvifdraqkrvgfaaspcaeia
gaavseisgpfstedvasncvp

Sequence, based on observed residues (ATOM records):

>d3zkib_ b.50.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lamvdnlqgdsgrgyylemligtppqklqilvdtgssnfavagtphsyidtyfdtersst
yrskgfdvtvkytqgswtgfvgedlvtipkgfntsflvniatifesenfflpgikwngil
glayatlakpsssletffdslvtqanipnvfsmqmcganggslvlggiepslykgdiwyt
pikeewyyqieilkleiggqslnldcreynadkaivdsgttllrlpqkvfdavveavara
ssdgfwtgsqlacwttpwsyfpkisiylrdenssrsfritilpqlyiqpmmgyecyrfgi
spstnalvigatvmegfyvifdraqkrvgfaaspcaeiagaavseisgpfstedvasncv
p

Timeline for d3zkib_:

• d3zkib_ first appeared in SCOPe 2.03
  
• d3zkib_ appears in SCOPe 2.05
  
• d3zkib_ appears in SCOPe 2.07
  
• d3zkib_ appears in the current release, SCOPe 2.08