SCOPe 2.03: Domain d3w5ea_: 3w5e A:

Lineage for d3w5ea_ (3w5e A:)

1. Root: SCOPe 2.03

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families)

5. Family a.211.1.2: PDEase [48548] (7 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b [48549] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48550] (28 PDB entries)
   Uniprot Q07343 324-667

8. Domain d3w5ea_: 3w5e A: [218212]
   automated match to d1f0ja_
   complexed with ca, nvw, zn

Details for d3w5ea_

PDB Entry: 3w5e, 2.3 Å

PDB Description: crystal structure of phosphodiesterase 4b in complex with compound 31e

PDB Compounds: (A:) cAMP-specific 3',5'-cyclic phosphodiesterase 4B

SCOPe Domain Sequences for d3w5ea_:

Sequence, based on SEQRES records:

>d3w5ea_ a.211.1.2 (A:) Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b {Human (Homo sapiens) [TaxId: 9606]}
srfgvntenedhlakeledlnkwglnifnvagyshnrpltcimyaifqerdllktfriss
dtfitymmtledhyhsdvayhnslhaadvaqsthvllstpaldavftdleilaaifaaai
hdvdhpgvsnqflintnselalmyndesvlenhhlavgfkllqeehcdifmnltkkqrqt
lrkmvidmvlatdmskhmslladlktmvetkkvtssgvllldnytdriqvlrnmvhcadl
snptkslelyrqwtdrimeeffqqgdkerergmeispmcdkhtasveksqvgfidyivhp
lwetwadlvqpdaqdildtlednrnwyqsmipqspsppldeqnrdcqglmekfqfelt

Sequence, based on observed residues (ATOM records):

>d3w5ea_ a.211.1.2 (A:) Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b {Human (Homo sapiens) [TaxId: 9606]}
srfgvntenedhlakeledlnkwglnifnvagyshnrpltcimyaifqerdllktfriss
dtfitymmtledhyhsdvayhnslhaadvaqsthvllstpaldavftdleilaaifaaai
hdvdhpgvsnqflintnselalmyndesvlenhhlavgfkllqeehcdifmnltkkqrqt
lrkmvidmvlatdmskhmslladlktmvetkkvtssgvllldnytdriqvlrnmvhcadl
snptkslelyrqwtdrimeeffqqgdkerergmeispmcdkhtasveksqvgfidyivhp
lwetwadlvqpdaqdildtlednrnwyqsmipcqglmekfqfelt

Timeline for d3w5ea_:

• d3w5ea_ is new in SCOPe 2.03-stable
  
• d3w5ea_ appears in SCOPe 2.04
  
• d3w5ea_ appears in the current release, SCOPe 2.08