SCOPe 2.07: Domain d3vs1a2: 3vs1 A:147-249

Lineage for d3vs1a2 (3vs1 A:147-249)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.93: SH2-like [55549] (1 superfamily)
   3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flanked by two helices

4. Superfamily d.93.1: SH2 domain [55550] (2 families)

5. Family d.93.1.1: SH2 domain [55551] (35 proteins)
   Pfam PF00017

6. Protein Hemopoetic cell kinase Hck [55565] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55566] (23 PDB entries)

8. Domain d3vs1a2: 3vs1 A:147-249 [218065]
   Other proteins in same PDB: d3vs1a1, d3vs1a3, d3vs1a4, d3vs1b1, d3vs1b3, d3vs1b4
   automated match to d1qcfa2
   complexed with ca, cl, vsa

Details for d3vs1a2

PDB Entry: 3vs1, 2.46 Å

PDB Description: Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea

PDB Compounds: (A:) Tyrosine-protein kinase HCK

SCOPe Domain Sequences for d3vs1a2:

Sequence, based on SEQRES records:

>d3vs1a2 d.93.1.1 (A:147-249) Hemopoetic cell kinase Hck {Human (Homo sapiens) [TaxId: 9606]}
eewffkgisrkdaerqllapgnmlgsfmirdsettkgsyslsvrdydprqgdtvkhykir
tldnggfyisprstfstlqelvdhykkgndglcqklsvpcmss

Sequence, based on observed residues (ATOM records):

>d3vs1a2 d.93.1.1 (A:147-249) Hemopoetic cell kinase Hck {Human (Homo sapiens) [TaxId: 9606]}
eewffkgisrkdaerqllapgnmlgsfmirdsettkgsyslsvrdydprqgdtvkhykir
sprstfstlqelvdhykkgndglcqklsvpcmss

Timeline for d3vs1a2:

• d3vs1a2 first appeared in SCOPe 2.03
  
• d3vs1a2 appears in SCOPe 2.06
  
• d3vs1a2 appears in the current release, SCOPe 2.08