Lineage for d3vbya_ (3vby A:)

  1. Root: SCOPe 2.05
  2. 1886641Class d: Alpha and beta proteins (a+b) [53931] (381 folds)
  3. 1929110Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 1929111Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 1929232Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 1931284Protein Proto-oncogene serine/threonine-protein kinase Pim-1 [118133] (1 species)
    OPK group(?); PIM subfamily; serine/threonine kinase
  7. 1931285Species Human (Homo sapiens) [TaxId:9606] [118134] (68 PDB entries)
    Uniprot P11309 33-305 ! Uniprot P11309 32-308
  8. 1931329Domain d3vbya_: 3vby A: [217755]
    automated match to d3r04a_
    complexed with 0fr, imd

Details for d3vbya_

PDB Entry: 3vby (more details), 2.27 Å

PDB Description: Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
PDB Compounds: (A:) Serine/threonine-protein kinase pim-1

SCOPe Domain Sequences for d3vbya_:

Sequence, based on SEQRES records: (download)

>d3vbya_ d.144.1.7 (A:) Proto-oncogene serine/threonine-protein kinase Pim-1 {Human (Homo sapiens) [TaxId: 9606]}
esqyqvgpllgsggfgsvysgirvsdnlpvaikhvekdrisdwgelpngtrvpmevvllk
kvssgfsgvirlldwferpdsfvlilerpepvqdlfdfitergalqeelarsffwqvlea
vrhchncgvlhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvysppewir
yhryhgrsaavwslgillydmvcgdipfehdeeiirgqvffrqrvssecqhlirwclalr
psdrptfeeiqnhpwmqdvllpqetaeihlh

Sequence, based on observed residues (ATOM records): (download)

>d3vbya_ d.144.1.7 (A:) Proto-oncogene serine/threonine-protein kinase Pim-1 {Human (Homo sapiens) [TaxId: 9606]}
esqyqvgpllgsggfgsvysgirvsdnlpvaikhvekdrisdwgetrvpmevvllkkvss
gfsgvirlldwferpdsfvlilerpepvqdlfdfitergalqeelarsffwqvleavrhc
hncgvlhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvysppewiryhry
hgrsaavwslgillydmvcgdipfehdeeiirgqvffrqrvssecqhlirwclalrpsdr
ptfeeiqnhpwmqdvllpqetaeihlh

SCOPe Domain Coordinates for d3vbya_:

Click to download the PDB-style file with coordinates for d3vbya_.
(The format of our PDB-style files is described here.)

Timeline for d3vbya_: