SCOPe 2.08: Domain d3v5qb1: 3v5q B:530-832

Lineage for d3v5qb1 (3v5q B:530-832)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d3v5qb1: 3v5q B:530-832 [217674]
   Other proteins in same PDB: d3v5qa2, d3v5qb2
   automated match to d3rhxa_
   complexed with 0f4, cl

Details for d3v5qb1

PDB Entry: 3v5q, 2.2 Å

PDB Description: discovery of a selective trk inhibitor with efficacy in rodent cancer tumor models

PDB Compounds: (B:) NT-3 growth factor receptor

SCOPe Domain Sequences for d3v5qb1:

Sequence, based on SEQRES records:

>d3v5qb1 d.144.1.0 (B:530-832) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vqhikrrdivlkrelgegafgkvflaecynlsptkdkmlvavkalkdptlaarkdfqrea
elltnlqhehivkfygvcgdgdplimvfeymkhgdlnkflrahgpdamilvdgqprqakg
elglsqmlhiasqiasgmvylasqhfvhrdlatrnclvganllvkigdfgmsrdvystdy
yrvgghtmlpirwmppesimyrkfttesdvwsfgvilweiftygkqpwfqlsntevieci
tqgrvlerprvcpkevydvmlgcwqrepqqrlnikeiykilhalgkatp

Sequence, based on observed residues (ATOM records):

>d3v5qb1 d.144.1.0 (B:530-832) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vqhikrrdivlkrelgfkvflaecynlsptkdkmlvavkalkdptlaarkdfqreaellt
nlqhehivkfygvcgdplimvfeymkhgdlnkflrahgpelglsqmlhiasqiasgmvyl
asqhfvhrdlatrnclvganllvkigdfgmdvystdyyrtmlpirwmppesimyrkftte
sdvwsfgvilweiftygkqpwfqlsnteviecitqgrvlerprvcpkevydvmlgcwqre
pqqrlnikeiykilhalgkatp

Timeline for d3v5qb1:

• d3v5qb1 first appeared in SCOPe 2.03, called d3v5qb_
  
• d3v5qb1 appears in SCOPe 2.07