Lineage for d3umxa_ (3umx A:)

  1. Root: SCOPe 2.05
  2. 1886641Class d: Alpha and beta proteins (a+b) [53931] (381 folds)
  3. 1929110Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 1929111Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 1929232Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 1931284Protein Proto-oncogene serine/threonine-protein kinase Pim-1 [118133] (1 species)
    OPK group(?); PIM subfamily; serine/threonine kinase
  7. 1931285Species Human (Homo sapiens) [TaxId:9606] [118134] (68 PDB entries)
    Uniprot P11309 33-305 ! Uniprot P11309 32-308
  8. 1931337Domain d3umxa_: 3umx A: [217454]
    automated match to d3jy0a_
    complexed with q18, so4

Details for d3umxa_

PDB Entry: 3umx (more details), 2.55 Å

PDB Description: Crystal structure of Pim1 kinase in complex with inhibitor (Z)-2-[(1H-indol-3-yl)methylene]-7-(azepan-1-ylmethyl)-6-hydroxybenzofuran-3(2H)-one
PDB Compounds: (A:) Proto-oncogene serine/threonine-protein kinase Pim-1

SCOPe Domain Sequences for d3umxa_:

Sequence, based on SEQRES records: (download)

>d3umxa_ d.144.1.7 (A:) Proto-oncogene serine/threonine-protein kinase Pim-1 {Human (Homo sapiens) [TaxId: 9606]}
qyqvgpllgsggfgsvysgirvsdnlpvaikhvekdrisdwgelpngtrvpmevvllkkv
ssgfsgvirlldwferpdsfvlilerpepvqdlfdfitergalqeelarsffwqvleavr
hchncgvlhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvysppewiryh
ryhgrsaavwslgillydmvcgdipfehdeeiirgqvffrqrvssecqhlirwclalrps
drptfeeiqnhpwmqdvllpqetaeihl

Sequence, based on observed residues (ATOM records): (download)

>d3umxa_ d.144.1.7 (A:) Proto-oncogene serine/threonine-protein kinase Pim-1 {Human (Homo sapiens) [TaxId: 9606]}
qyqvgpllgsggfgsvysgirvnlpvaikhvekdrisdwgervpmevvllkkvssgfsgv
irlldwferpdsfvlilerpepvqdlfdfitergalqeelarsffwqvleavrhchncgv
lhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvysppewiryhryhgrsa
avwslgillydmvcgdipfehdeeiirgqvffrqrvssecqhlirwclalrpsdrptfee
iqnhpwmqdvllpqetaeihl

SCOPe Domain Coordinates for d3umxa_:

Click to download the PDB-style file with coordinates for d3umxa_.
(The format of our PDB-style files is described here.)

Timeline for d3umxa_: