SCOPe 2.06: Domain d3ug8a_: 3ug8 A:

Lineage for d3ug8a_ (3ug8 A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (2 families)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (16 proteins)
   Common fold covers whole protein structure

6. Protein Prostaglandin d2 11-ketoreductase (akr1c3) [102051] (1 species)
   Aldo-keto reductase family 1 member c3

7. Species Human (Homo sapiens) [TaxId:9606] [102052] (43 PDB entries)
   Uniprot P42330

8. Domain d3ug8a_: 3ug8 A: [217362]
   automated match to d4h7ca_
   complexed with edo, imn, nap

Details for d3ug8a_

PDB Entry: 3ug8, 1.73 Å

PDB Description: AKR1C3 complex with indomethacin at pH 7.5

PDB Compounds: (A:) Aldo-keto reductase family 1 member C3

SCOPe Domain Sequences for d3ug8a_:

Sequence, based on SEQRES records:

>d3ug8a_ c.1.7.1 (A:) Prostaglandin d2 11-ketoreductase (akr1c3) {Human (Homo sapiens) [TaxId: 9606]}
qcvklndghfmpvlgfgtyappevprskalevtklaieagfrhidsahlynneeqvglai
rskiadgsvkredifytsklwstfhrpelvrpalenslkkaqldyvdlylihspmslkpg
eelsptdengkvifdivdlcttweamekckdaglaksigvsnfnrrqlemilnkpglkyk
pvcnqvechpyfnrsklldfckskdivlvaysalgsqrdkrwvdpnspvlledpvlcala
kkhkrtpalialryqlqrgvvvlaksyneqrirqnvqvfefqltaedmkaidgldrnlhy
fnsdsfashpnypysd

Sequence, based on observed residues (ATOM records):

>d3ug8a_ c.1.7.1 (A:) Prostaglandin d2 11-ketoreductase (akr1c3) {Human (Homo sapiens) [TaxId: 9606]}
qcvklndghfmpvlgfgtyappevprskalevtklaieagfrhidsahlynneeqvglai
rskiadgsvkredifytsklwstfhrpelvrpalenslkkaqldyvdlylihspmslkpi
fdivdlcttweamekckdaglaksigvsnfnrrqlemilnkpglkykpvcnqvechpyfn
rsklldfckskdivlvaysalgsqrdkrwvdpnspvlledpvlcalakkhkrtpalialr
yqlqrgvvvlaksyneqrirqnvqvfefqltaedmkaidgldrnlhyfnsdsfashpnyp
ysd

Timeline for d3ug8a_:

• d3ug8a_ first appeared in SCOPe 2.03
  
• d3ug8a_ appears in SCOPe 2.05
  
• d3ug8a_ appears in SCOPe 2.07
  
• d3ug8a_ appears in the current release, SCOPe 2.08