SCOPe 2.03: Domain d3u4ib_: 3u4i B:

Lineage for d3u4ib_ (3u4i B:)

1. Root: SCOPe 2.03

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.23: Flavodoxin-like [52171] (15 superfamilies)
   3 layers, a/b/a; parallel beta-sheet of 5 strand, order 21345

4. Superfamily c.23.14: N-(deoxy)ribosyltransferase-like [52309] (4 families)
   there are similar active site architectures as well as the catalytic mechanisms of functionally characterised members

5. Family c.23.14.3: ADP ribosyl cyclase-like [56630] (3 proteins)
   contains extra N-terminal all-alpha subdomain
   automatically mapped to Pfam PF02267

6. Protein ADP ribosyl cyclase [56631] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [159490] (32 PDB entries)
   Uniprot P28907 45-291

8. Domain d3u4ib_: 3u4i B: [217192]
   automated match to d2i66a_
   complexed with cvr

Details for d3u4ib_

PDB Entry: 3u4i, 2.12 Å

PDB Description: CD38 structure-based inhibitor design using the N1-cyclic inosine 5'-diphosphate ribose template

PDB Compounds: (B:) ADP-ribosyl cyclase 1

SCOPe Domain Sequences for d3u4ib_:

Sequence, based on SEQRES records:

>d3u4ib_ c.23.14.3 (B:) ADP ribosyl cyclase {Human (Homo sapiens) [TaxId: 9606]}
rwrqtwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcditee
dyqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdltwcgefd
tskinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfgs
vevhnlqpekvqtleawvihggredsrdlcqdptikelesiiskrniqfsckniyrpdkf
lqcvk

Sequence, based on observed residues (ATOM records):

>d3u4ib_ c.23.14.3 (B:) ADP ribosyl cyclase {Human (Homo sapiens) [TaxId: 9606]}
rwrqtwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcditee
dyqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdltwcgefd
tskinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfgs
vevhnlqpekvqtleawvihsrdlcqdptikelesiiskrniqfsckniyrpdkflqcvk

Timeline for d3u4ib_:

• d3u4ib_ is new in SCOPe 2.03-stable
  
• d3u4ib_ appears in SCOPe 2.04
  
• d3u4ib_ appears in the current release, SCOPe 2.08