SCOPe 2.08: Domain d3tnwc_: 3tnw C:

Lineage for d3tnwc_ (3tnw C:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (417 PDB entries)
   Uniprot P24941

8. Domain d3tnwc_: 3tnw C: [216910]
   Other proteins in same PDB: d3tnwa2, d3tnwb1, d3tnwb2, d3tnwd1, d3tnwd2
   automated match to d3bhta_
   complexed with f18, na

Details for d3tnwc_

PDB Entry: 3tnw, 2 Å

PDB Description: Structure of CDK2/cyclin A in complex with CAN508

PDB Compounds: (C:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d3tnwc_:

Sequence, based on SEQRES records:

>d3tnwc_ d.144.1.7 (C:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvp

Sequence, based on observed residues (ATOM records):

>d3tnwc_ d.144.1.7 (C:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigeggvvykarnkltgevvalkkirldtetegvpstaireisllkelnhpn
ivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshr
vlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyyst
avdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpk
warqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvp

Timeline for d3tnwc_:

• d3tnwc_ first appeared in SCOPe 2.03
  
• d3tnwc_ appears in SCOPe 2.07