SCOPe 2.03: Domain d3srkb2: 3srk B:88-186

Lineage for d3srkb2 (3srk B:88-186)

1. Root: SCOPe 2.03

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.58: PK beta-barrel domain-like [50799] (1 superfamily)
   barrel, closed; n=7, S=10; complex topology

4. Superfamily b.58.1: PK beta-barrel domain-like [50800] (2 families)

5. Family b.58.1.1: Pyruvate kinase beta-barrel domain [50801] (1 protein)
   this domain interrupts beta/alpha-barrel domain
   C-terminal domain is alpha/beta

6. Protein Pyruvate kinase (PK) [50802] (6 species)

7. Species Trypanosome (Leishmania mexicana) [TaxId:5665] [50805] (11 PDB entries)

8. Domain d3srkb2: 3srk B:88-186 [216526]
   Other proteins in same PDB: d3srka1, d3srka3, d3srkb1, d3srkb3
   automated match to d1pkla1
   complexed with k, lsa, ptk

Details for d3srkb2

PDB Entry: 3srk, 2.65 Å

PDB Description: A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase

PDB Compounds: (B:) pyruvate kinase

SCOPe Domain Sequences for d3srkb2:

Sequence, based on SEQRES records:

>d3srkb2 b.58.1.1 (B:88-186) Pyruvate kinase (PK) {Trypanosome (Leishmania mexicana) [TaxId: 5665]}
eirtgqfvggdavmergatcyvttdpafadkgtkdkfyidyqnlskvvrpgnyiyiddgi
lilqvqshedeqtlectvtnshtisdrrgvnlpgcdvdl

Sequence, based on observed residues (ATOM records):

>d3srkb2 b.58.1.1 (B:88-186) Pyruvate kinase (PK) {Trypanosome (Leishmania mexicana) [TaxId: 5665]}
evnlpgcdvdl

Timeline for d3srkb2:

• d3srkb2 appears in SCOPe 2.04
  
• d3srkb2 appears in the current release, SCOPe 2.07