Lineage for d3srka3 (3srk A:358-498)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2120383Fold c.49: Pyruvate kinase C-terminal domain-like [52934] (2 superfamilies)
    3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145, strand 5 is antiparallel to the rest
  4. 2120384Superfamily c.49.1: PK C-terminal domain-like [52935] (2 families) (S)
  5. 2120385Family c.49.1.1: Pyruvate kinase, C-terminal domain [52936] (1 protein)
    automatically mapped to Pfam PF02887
  6. 2120386Protein Pyruvate kinase, C-terminal domain [52937] (6 species)
  7. 2120486Species Trypanosome (Leishmania mexicana) [TaxId:5665] [52940] (11 PDB entries)
  8. 2120523Domain d3srka3: 3srk A:358-498 [216524]
    Other proteins in same PDB: d3srka1, d3srka2, d3srkb1, d3srkb2
    automated match to d1pkla3
    complexed with k, lsa, ptk

Details for d3srka3

PDB Entry: 3srk (more details), 2.65 Å

PDB Description: A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase
PDB Compounds: (A:) pyruvate kinase

SCOPe Domain Sequences for d3srka3:

Sequence, based on SEQRES records: (download)

>d3srka3 c.49.1.1 (A:358-498) Pyruvate kinase, C-terminal domain {Trypanosome (Leishmania mexicana) [TaxId: 5665]}
neyvffnsikklqhipmsadeavcssavnsvyetkakamvvlsntgrsarlvakyrpncp
ivcvttrlqtcrqlnitqgvesvffdadklghdegkehrvaagvefakskgyvqtgdycv
vihadhkvkgyanqtrillve

Sequence, based on observed residues (ATOM records): (download)

>d3srka3 c.49.1.1 (A:358-498) Pyruvate kinase, C-terminal domain {Trypanosome (Leishmania mexicana) [TaxId: 5665]}
neyvffnsikklqhipmsadeavcssavnsvyetkakamvvlsntgrsarlvakyrpncp
ivcvttrlqtcrqlnitqgvesvffdadklghdegkehrvaagvefakskgyvqtgdycv
vihayanqtrillve

SCOPe Domain Coordinates for d3srka3:

Click to download the PDB-style file with coordinates for d3srka3.
(The format of our PDB-style files is described here.)

Timeline for d3srka3: