SCOPe 2.08: Domain d3slsa1: 3sls A:45-345

Lineage for d3slsa1 (3sls A:45-345)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d3slsa1: 3sls A:45-345 [216479]
   Other proteins in same PDB: d3slsa2, d3slsb2
   automated match to d1s9ia_
   complexed with 77d, anp, mg

Details for d3slsa1

PDB Entry: 3sls, 2.3 Å

PDB Description: Crystal Structure of human MEK-1 kinase in complex with UCB1353770 and AMPPNP

PDB Compounds: (A:) Dual specificity mitogen-activated protein kinase kinase 1

SCOPe Domain Sequences for d3slsa1:

Sequence, based on SEQRES records:

>d3slsa1 d.144.1.7 (A:45-345) automated matches {Human (Homo sapiens) [TaxId: 9606]}
qqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarklihleik
pairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkkagripeq
ilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmansfv
gtrsymsperlqgthysvqsdiwsmglslvemavgrypigsgsgsmaifelldyivnepp
pklpsgvfslefqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstigln
q

Sequence, based on observed residues (ATOM records):

>d3slsa1 d.144.1.7 (A:45-345) automated matches {Human (Homo sapiens) [TaxId: 9606]}
qqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarklihleik
pairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkkagripeq
ilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlifvgtrsym
sperlqgthysvqsdiwsmglslvemavgrypigaifelldyivnepppklpsgvfslef
qdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstiglnq

Timeline for d3slsa1:

• d3slsa1 first appeared in SCOPe 2.03, called d3slsa_
  
• d3slsa1 appears in SCOPe 2.07