SCOPe 2.07: Domain d3shya_: 3shy A:

Lineage for d3shya_ (3shy A:)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families)

5. Family a.211.1.2: PDEase [48548] (7 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein automated matches [190370] (2 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187208] (37 PDB entries)

8. Domain d3shya_: 3shy A: [216416]
   automated match to d3siea_
   complexed with 5fo, mg, zn

Details for d3shya_

PDB Entry: 3shy, 2.65 Å

PDB Description: crystal structure of the pde5a1 catalytic domain in complex with novel inhibitors

PDB Compounds: (A:) cGMP-specific 3',5'-cyclic phosphodiesterase

SCOPe Domain Sequences for d3shya_:

Sequence, based on SEQRES records:

>d3shya_ a.211.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
etrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhevl
crwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshdl
dhrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykttlki
ikqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiq
qriaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealthv
sedcfplldgcrknrqkwqalaeqq

Sequence, based on observed residues (ATOM records):

>d3shya_ a.211.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
etrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhevl
crwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshdl
dhrgvnnsyiqrsehsimehhhfdqclmilnspgnqilsglsieeykttlkiikqailat
dlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqqriaelva
teffdqkknkipsmqvgfidaiclqlyealthvsedcfplldgcrknrqkwqalaeqq

Timeline for d3shya_:

• d3shya_ first appeared in SCOPe 2.03
  
• d3shya_ appears in SCOPe 2.06
  
• d3shya_ appears in the current release, SCOPe 2.08