SCOPe 2.07: Domain d3rx2a1: 3rx2 A:0-315

Lineage for d3rx2a1 (3rx2 A:0-315)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (2 families)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (16 proteins)
   Common fold covers whole protein structure

6. Protein Aldose reductase (aldehyde reductase) [51436] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51437] (155 PDB entries)
   Uniprot P15121

8. Domain d3rx2a1: 3rx2 A:0-315 [216108]
   Other proteins in same PDB: d3rx2a2
   automated match to d3caqb_
   complexed with nap, slo

Details for d3rx2a1

PDB Entry: 3rx2, 1.9 Å

PDB Description: Crystal Structure of Human Aldose Reductase Complexed with Sulindac Sulfone

PDB Compounds: (A:) aldose reductase

SCOPe Domain Sequences for d3rx2a1:

Sequence; same for both SEQRES and ATOM records:

>d3rx2a1 c.1.7.1 (A:0-315) Aldose reductase (aldehyde reductase) {Human (Homo sapiens) [TaxId: 9606]}
masrlllnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiq
eklreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgk
effpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykp
avnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaak
hnkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvca
llsctshkdypfheef

Timeline for d3rx2a1:

• d3rx2a1 first appeared in SCOPe 2.03, called d3rx2a_
  
• d3rx2a1 appears in SCOPe 2.06
  
• d3rx2a1 appears in the current release, SCOPe 2.08